Are Genetically Robust Regulatory Networks Dynamically Different from Random Ones?

We study a genetic regulatory network model developed to demonstrate that genetic robustness can evolve through stabilizing selection for optimal phenotypes. We report preliminary results on whether such selection could result in a reorganization of the state space of the system. For the chosen parameters, the evolution moves the system slightly toward the more ordered part of the phase diagram. We also find that strong memory effects cause the Derrida annealed approximation to give erroneous predictions about the model's phase diagram.Comment: To be published in Computer Simulation Studies in Condensed-Matter Physics XX. Ed. by D.P. Landau, S. P. Lewis, H.-B. Schuttler (Springer-Verlag, Berlin Heidelberg New York

The effectiveness of cognitive behavioral therapy including updating the early life experiences and images with the empty chair technique on social anxiety

Specific memories of early negative life experiences (ENLE) and images play an important role in the cause and persistence of social anxiety. In this study, we aimed to investigate the effectiveness of individual Cognitive Behavior Therapy (iCBT), which includes updating a specific memory of ENLE and related images using the empty chair technique, on the social anxiety of university students. In addition to this, how iCBT applied affects the students' general self efficacy and psychological well-being is also examined. The current study was carried out with a total of eight university students, six female and two male. Participants attended iCBT sessions for 12 weeks. Changes in participants were evaluated with Liebowitz Social Anxiety Scale (LSAS), General Self-Efficacy Scale (GSES), and Flourishing Scale (FS) before iCBT, and one week, three months and six months after iCBT ended. The findings show that participants' social anxiety decreased both statistically and clinically in post-tests and follow-up measures. There were statistically and clinically significant increases in general self-efficacy and psychological well-being. In addition, the changes in the participants' social anxiety, general self-efficacy and psychological well-being post-test and follow-up measures have a large effect size. This study shows that iCBT, which includes updating of specific memories of ENLE and images, is effective in reducing social anxiety and increasing general self-efficacy and psychological well-being. These findings show that iCBT, which includes updating a specific memory of ENLE and related images, using the empty chair technique is an effective method reducing for university students' social anxiety

Academic Rigor: A Research Report

Rigor can be defined in any number of ways. We found an imbalance between the ways in which rigor has been defined by the Virginia Department of Education, and how education scholars define rigor in the respective academic disciplines. (1) The Commonwealth of Virginia defines rigor as college and career readiness as measured by attendance in post-secondary educational institution, achievement of high Standards of Learning (SOL) test scores, as well as participation in Advanced Placement and International Baccalaureate programs. (2) Educational Psychologists tend to define rigor in ways that are generalizable across contexts. Researchers in this tradition focus on academic press, or the extent to which educational stakeholders, including students, are oriented towards demanding coursework. Studies in this tradition have also found that student motivation is crucial, and that this motivation is mediated by the extent to which tasks are challenging, related to the world outside of school, and provide opportunities for students to collaborate when problem solving. (3) Discipline-Based Scholars of Teaching and Learning define rigor in ways that reflect the core concepts of their discipline. Thus, a rigorous math class is one where students are encouraged to think mathematically, i.e. to use mathematical approaches to solve problems. Although specific pedagogical styles are discussed in this literature, the overall emphasis is on depth rather than breadth, with curricula being designed around building understanding of key concepts rather than covering (or efficiently delivering) factual information and procedural steps. In other words, a US history course might be organized around the way that the idea of freedom developed over the course of US history

Academic Rigor for All: A Review of Literature

In this literature review, we will attempt to address the issue of academic rigor in several ways. First, we will review federal and Virginia policy documents that discuss academic rigor, and the research reports that influenced these documents. We will then attempt to articulate a clear definition of academic rigor that applies across academic contexts. This definition draws on the work of educational psychologists, sociologists, and scholars of teaching and learning. Finally we will review the research literature on rigorous classroom practice in two disciplines, history and mathematics

Effects of Preference for Attachment to Low-degree Nodes on the Degree Distributions of a Growing Directed Network and a Simple Food-Web Model

We study the growth of a directed network, in which the growth is constrained by the cost of adding links to the existing nodes. We propose a new preferential-attachment scheme, in which a new node attaches to an existing node i with probability proportional to 1/k_i, where k_i is the number of outgoing links at i. We calculate the degree distribution for the outgoing links in the asymptotic regime (t->infinity), both analytically and by Monte Carlo simulations. The distribution decays like k c^k/Gamma(k) for large k, where c is a constant. We investigate the effect of this preferential-attachment scheme, by comparing the results to an equivalent growth model with a degree-independent probability of attachment, which gives an exponential outdegree distribution. Also, we relate this mechanism to simple food-web models by implementing it in the cascade model. We show that the low-degree preferential-attachment mechanism breaks the symmetry between in- and outdegree distributions in the cascade model. It also causes a faster decay in the tails of the outdegree distributions for both our network growth model and the cascade model.Comment: 10 pages, 7 figures. A new figure added. Minor modifications made in the tex

Network Growth with Preferential Attachment for High Indegree and Low Outdegree

We study the growth of a directed transportation network, such as a food web, in which links carry resources. We propose a growth process in which new nodes (or species) preferentially attach to existing nodes with high indegree (in food-web language, number of prey) and low outdegree (or number of predators). This scheme, which we call inverse preferential attachment, is intended to maximize the amount of resources available to each new node. We show that the outdegree (predator) distribution decays at least exponentially fast for large outdegree and is continuously tunable between an exponential distribution and a delta function. The indegree (prey) distribution is poissonian in the large-network limit

Urban share of the "burden" : impact of a support organisation on caregiver burden of people affected by dementia

Purpose. This study investigated the experiences and expectations of unpaid caregivers who were members of a nonprofit social support organisation. Design and Methods. Colaizzi's phenomenological exploration was followed. Data were saturated after 15 in-depth individual interviews at a centre for people affected with dementia. Findings. The themes reported with the COREQ checklist were contributory to caregiver burden, the escalation of dementia symptoms, changes in family roles, psychological distress, social challenges, membership in a social network, and developing effective coping skills. Practice Implications. Access, availability, and continuity of psychosocial support programs are vital for the wellbeing of people affected with dementia

Is local resection sufficient for parathyroid carcinoma?

OBJECTIVES: Parathyroid carcinoma is a rare malignant disease of the parathyroid glands that appears in less than 1% of patients with primary hyperparathyroidism. In the literature, the generally recommended treatment is en bloc tumor excision with ipsilateral thyroid lobectomy. Based on our 12 years of experience, we discuss the necessity of performing thyroid lobectomy on parathyroid carcinoma patients. RESULTS: Eleven parathyroid carcinoma cases were included in the study. All operations were performed at the Department of Endocrine Surgery at Ankara University Medical School. Seven of the patients were male (63.6%), and the mean patient age was 48.9 ± 14.0 years. Hyperparathyroidism was the most common indication for surgery (n ϝ 10, 90.9%). Local disease was detected in 5 patients (45.5%), invasive disease was detected in 5 patients (45.5%) and metastatic disease was detected in 1 patient (9.1%). The mean follow-up period was 99.6 ± 42.1 months, and the patients' average disease-free survival was 96.0 ± 49.0 months. During the follow-up period, only 1 patient died of metastatic parathyroid carcinoma. CONCLUSION: Parathyroid carcinoma has a slow-growing natural progression, and regional lymph node metastases are uncommon. Although our study comprised few patients, it nevertheless showed that in selected cases, parathyroid carcinoma could be solely treated with parathyroidectomy

Breast hamartoma: a clinicopathologic analysis of 27 cases and a literature review

OBJECTIVES: Breast hamartoma is an uncommon breast tumor that accounts for approximately 4.8% of all benign breast masses. The pathogenesis is still poorly understood and breast hamartoma is not a well-known disorder, so its diagnosis is underestimated by clinicians and pathologists. This study was designed to present our experience with breast hamartoma, along with a literature review. METHOD: We reviewed the demographic data, pathologic analyses and imaging and results of patients diagnosed with breast hamartoma between December 2003 and September 2013. RESULTS: In total, 27 cases of breast hamartoma operated in the Ankara University Medicine Faculty's Department of General Surgery were included in the study. All patients were female and the mean age was 41.8±10.8 years. The mean tumor size was 3.9±2.7 cm. Breast ultrasound was performed on all patients before surgery. The most common additional lesion was epithelial hyperplasia (22.2%). Furthermore, lobular carcinoma in situ was identified in one case and invasive ductal carcinoma was observed in another case. Immunohistochemical staining revealed myoid hamartoma in one case (3.7%). CONCLUSION: Breast hamartomas are rare benign lesions that may be underdiagnosed because of the categorization of hamartomas as fibroadenomas by pathologists. Pathologic examinations can show variability from one case to another. Thus, the true incidence may be higher than the literature indicates